Lachin Doxycycline Hyclate manifaktirè yo ak founisè |CPF

Doxycycline Hyclate

Deskripsyon kout:

Non API a	Endikasyon	Spesifikasyon	US DMF	Inyon Ewopeyen DMF	KEP
Doxycycline Hyclate	Antibyotik	USP/EP	13771	√

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Doxycycline hyclate se yon antibyotik [1].

Doxycycline hyclate se yon dérivés de tetrasiklin ak posede aktivite yo nan anti-enflamatwa ak antimikwòb.Doxycycline inibit replikasyon viris deng nan vitro ak yon fason ki depann de tanperati a.Valè IC50 a se 52.3μM nan 37°C ak 26.7μM nan 40°C.Li inibit viris deng la atravè anpeche NS2B-NS3 serine proteaz viris la.60μM doxycycline diminye CPE selil ki enfekte DNEV2 yo [1].

Doxycycline yo jwenn yo dwe yon inibitè nan MMP.Tretman Doxycycline diminye nivo MMP-8 ak -9 epi anpeche ekspresyon tisi MMP-2 ak MMP-9.Anplis, tretman ak doxycycline siyifikativman diminye ensidans la nan anevrism entrakranyen.Doxycycline te rapòte tou se yon ajan anti-enflamatwa ki baze sou anpèchman li yo nan metaloproteinas matris.Anplis de sa, doxycycline gen pisan aktivite antimalarya ak valè IC50 nan 320nM nan 96h nan vitro [2, 3].

Referans:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Inhibitory effect of doxycycline kont replikasyon viris deng nan vitro.Arch Virol.2014 Apr;159(4):711-8.
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Wòl matris metalloproteinases (MMPs) ak inhibiteurs MMP sou anevrism entrakranyen: yon atik revizyon.Med J Islam Repub Iran.2013 Nov;27(4):249-254.
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.Nan vitro ak in vivo efikasite antimalarya nan optimize tetrasiklin.Ajan antimikwòb Chemother.2013 Jul;57(7):3131-6.

Deskripsyon

Doxycycline (hyclate) (Doxycycline hydrochloride emiethanolate hemihydrate), yon antibyotik, se yon inibitè metaloproteinaz (MMP) aktif oralman ak gwo spectre [1].

Esè klinik

Nimewo NCT	Sponsor	Kondisyon	Dat Kòmanse	Faz
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NCT01879930	Inivèsite Lopital Inselspital, Berne	Sendwòm Doulè Basen Kwonik \| Sendwòm Doulè nan Bladder	Novanm 2012	Faz 4
NCT00041977	CollaGenex Pharmaceuticals	Akne Rosacée	jen 2002	Faz 3
NCT02341209	Rochester Jeneral Lopital	Lenfom T-selil kutane\|Mikoz Fongoid\|Sendwòm Sezary	6 fevriye 2018	Faz 2
NCT00002872	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|North Central Cancer Treatment Group	Kansè metastatik	Novanm 1996	Faz 3
NCT03162497	Inivèsite Medikal nan Vyèn	Sendwòm Je Sèch \| Disfonksyon glann Meibomian	8 janvye 2018	Faz 4
NCT01418742	Gesellschaft four Medizinische Inovasyon ?Hamatologie und Onkologie mbH\|ClinAssess GmbH	Kansòm kolorektal	Out 2011	Faz 2
NCT00980148	Enstiti Nasyonal pou Alèji ak Maladi Enfektye (NIAID)	Enfeksyon klamidyal	Desanm 2009	Faz 3
NCT03342456	Twazyèm Lopital Xiangya nan Inivèsite Santral Sid\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm.Ind. co, Ltd.	Ilsè duodnal akòz Helicobacter Pylori	13 desanm 2017	Faz 4
NCT04310930	University of Queensland\|Depatman Sante Gouvènman Ostralyen\|Fondasyon Lopital Timoun yo\|Fondasyon Fibwoz Sistik\|Newcastle University\|Griffith University\|Erasmus Medical Center\|Monash University\|University of Copenhagen\|Hôpital Cochin\|South Australian Health and Medical Research Institute\|University nan Melbourne\|James Cook University, Queensland, Ostrali\|Murdoch Childrens Research Institute	Maladi Pulmonè Akòz Mikobakteri (Dyagnostik)	Mas 2020	Faz 2\| Faz 3
NCT03709459	Kirby Institute\|South Australian Health and Medical Research Institute\|Monash University	Prevansyon MST	17 desanm 2019
NCT04067011	Emergent BioSolutions\|Otorite rechèch ak devlopman avanse byomedikal	Anthrax	12 out 2019	Faz 2
NCT02844634	British Columbia Sant pou Kontwòl Maladi	VIH\|Sifilis	15 me 2018	Faz 4
NCT00647959	Mylan Pharmaceuticals	An sante	Mas 2006	Faz 1
NCT00170222	Sant Medikal Alkmaar	Maladi Pulmonè Obstriktif Kwonik	Jiyè 2002	Faz 4
NCT03075891	Galderma	Rosacée	5 jiyè 2017	Faz 4
NCT00031499	Enstiti Nasyonal pou Alèji ak Maladi Enfektye (NIAID)	Sifilis	jen 2000	Faz 3
NCT01205464	Inivèsite Linkoeping	Fatig\|Doulè Radikilè\|Malfonksyònman Kognitif\|Parestezi\|Parèz	Fevriye 2005	Pa aplikab
NCT01301586	Nexgen Dermatologics, Inc.	AKNE VULGARIS	Novanm 2010	Faz 1 \| Faz 2
NCT02305940	Imperial College London	Maladi Pulmonè Obstriktif Kwonik (COPD)	Jiyè 2014	Faz 3
NCT00351182	Dong-Min Kim\|Chosun University Hospital	Fwote Typhus	Septanm 2005	Faz 3
NCT03334682	Lopital Inivèsite Nantes	Akne vilgè	31 janvye 2018	Faz 3
NCT01788215	Inivèsite Rochester	Sendwòm òvèj polikistik (PCOS)\|Sik règ iregilye\|Depase androjèn	Novanm 2010	Faz 3
NCT03076281	Sidney Kimmel Cancer Center nan Thomas Jefferson University\|Thomas Jefferson University	Larenks\|LIP\|Kavite Oral\|Farinks	3 avril 2017	Faz 2
NCT00439166	Hamilton Health Sciences Corporation\|The Physicians' Services Incorporated Foundation\|McMaster University	Maladi alzayme	Fevriye 2007	Faz 3
NCT02463942	University Medical Center Ljubljana\|University of Ljubljana School of Medicine, Sloveni	Ansefalit ki bay tik	Septanm 2014	Pa aplikab
NCT00803842	Northwestern University	Kansè nan poumon ki pa ti selil	Oktòb 2008	Pa aplikab
NCT02086591	Inivèsite Rochester	Gwo lenfom selil B difize pou granmoun\|Lenfom selil manto renouvlab\|Lenfom, folikulèr\|Lenfom selil B nan zòn majinal\|Lenfom malfezan - lenfoplasmasitik\|Waldenstrom makroglobulinemi\|Ti lenfom lenfositik\|Lenfom lenfositik kwonik (CLL)\|Tenfom-	Mas 2014	Faz 2
NCT03980223	University of California, San Francisco\|University of Washington\|National Institute of Allergy and Infectious Diseases (NIAID)\|Mayne Pharma International Pty Ltd\|San Francisco Department of Public Health	Gonore\|Klamidya\|Sifilis	26 novanm 2019	Faz 4
NCT00355459	University of Texas Southwestern Medical Center	Sendwòm je sèk	Out 2005	Pa aplikab
NCT01254799	Omar Mamdouh Shaaban\|Assiut University	Emoraji nan matris	Janvye 2008	Faz 3
NCT01547325	NanoSHIFT LLC\|Depatman Defans Etazini	Blesi chirijikal dehisced	Me 2012	Pa aplikab
NCT00653380	Par Pharmaceutical, Inc.\|Anapharm	Pou Detèmine Byoekivalans Anba Kondisyon Jèn	Septanm 1999	Faz 1
NCT00635609	Warner Chilcott	Akne vilgè	Mas 2008	Faz 4
NCT03765931	Institut de Recherche pour le Developpement	Lafyèv	Jiyè 2016	Faz 4
NCT01160640	Harold Wiesenfeld\|Enstiti Nasyonal pou Alèji ak Maladi Enfektye (NIAID)\|University of Pittsburgh	Maladi enflamatwa basen	Novanm 2010	Faz 2
NCT01756833	University of Maryland, Baltimore\|National Institute on Aging (NIA)	Aneurism	Me 2013	Faz 2
NCT00688064	Galderma	Gwo akne vilgè	Out 2008	Faz 3
NCT01320033	Galderma	Akne vilgè	29 mas 2011	Faz 2
NCT03397004	St. Michael´s Hospital, Toronto\|Barrow Neurological Institute\|Duke University\|Feinstein Institute for Medical Research\|University of Pittsburgh\|Sunnybrook Health Sciences Center	Telangiectasia ereditè emorajik (HHT)	12 septanm 2018	Faz 2
NCT01635530	Turku Inivèsite Lopital	Lyme neroborrelioz	Out 2012	Faz 4
NCT03727620	Inivèsite Mohammed V Souissi	Parodontit agresif	6 janvye 2014	Faz 1 \| Faz 2
NCT02688738	Rothman Enstiti òtopedik	Propionibacterium	Mas 2015	Pa aplikab
NCT00358462	University of Washington\|Enstiti Nasyonal pou Alèji ak Maladi Enfektye (NIAID)	Uretrit	Janvye 2007	Faz 3
NCT02864550	British Columbia Sant pou Kontwòl Maladi	Sifilis\|Enfeksyon Transmèt Seksyèlman	15 out 2019	Faz 4
NCT01595594	University of Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Maladi Parodontal\|Dyabèt Tip 2	Mas 2010	Faz 3
NCT00964834	PharmAthene, Inc.\|National Institutes of Health (NIH)\|Medarex\|Quintiles, Inc.\|Depatman Sante ak Sèvis Imen	Anthrax	Jiyè 2009	Faz 1
NCT01809444	Inivèsite Sun Yat-sen	Oftalmopati ki asosye ak tiwoyid	Novanm 2012	Faz 2\| Faz 3
NCT01590082	MD Anderson Cancer Center\|National Institutes of Health (NIH)\|National Cancer Institute (NCI)	Melanom	Novanm 2012	Faz 1 \| Faz 2
NCT00207584	Sant pou Kontwòl ak Prevansyon Maladi	Mycoplasma Pneumoniae	Janvye 1994	Pa aplikab
NCT00775177	Ranbaxy Laboratories Limited\|Ranbaxy Inc.	An sante	jen 2005	Pa aplikab
NCT03462329	Inivèsite Sant Medikal Ljubljana	Eritem Migrans	1ye jen 2018	Pa aplikab
NCT00000403	Inivèsite Indiana\|Enstiti Nasyonal pou Atrit ak Maladi Miskiloskeletal ak Po (NIAMS)\|Enstiti Nasyonal pou Aje (NIA)	Osteoartrit	Septanm 1996	Faz 3
NCT03508232	University of Alberta\|Royal Alexandra Hospital	Elevasyon Segman ST Enfaktis Myokad\|Esifyans Kè	6 janvye 2020	Faz 2
NCT02553473	Lopital Sorlandet HF	Neuroborreliosis, Borrelia Burgdorferi	Oktòb 2015	Faz 3
NCT02207556	Kolèj Medikal nan Wisconsin	Primè amiloidoz sistemik	1ye oktòb 2014	Faz 2
NCT01783106	Royal Liverpool University Hospital\|National Association for Colitis and Crohn's Disease\|National Institute for Health Research, Wayòm Ini	Maladi Crohn	1ye fevriye 2014	Faz 2
NCT00353743	Lopital Klinik Porto Alegre	Avòtman, septik	Me 2006	Pa aplikab
NCT01727973	Inivèsite Sun Yat-sen	Graves Ophthalmopathy\|Maladi Graves\|Maladi Je\|Maladi Tiwoyid\|Maladi Sistèm Endokrin\|Maladi Je, Ereditè\|Ipètiwoyid\|Maladi Otoiminitè\|Maladi Sistèm Iminitè	Oktòb 2012	Faz 1 \| Faz 2
NCT00857038	Medical Center Alkmaar\|Leiden University Medical Center\|University of Amsterdam	Maladi Pulmonè Obstriktif Kwonik\|Enflamasyon\|Anfizèm Pulmonè	Avril 2009	Faz 4
NCT02774993	National University Hospital, Singapore\|Tan Tock Seng Hospital\|National University, Singapore\|A*Star	Tibèkiloz	Septanm 2015	Faz 2
NCT03474458	IRCCS Poliklinik S. Matteo	Amyloidoz AL kadyak	11 fevriye 2019	Faz 2\| Faz 3
NCT02874430	Sidney Kimmel Cancer Center nan Thomas Jefferson University\|Thomas Jefferson University	Kansòm nan tete\|Adenokansòm selil andometrik klè\|Adenokansòm sereuz andomèt\|Kansè kò matris\|Kansòm kòs matris	8 jen 2016	Faz 2
NCT00016835	University of Michigan\|Enstiti Nasyonal pou Rechèch Dantè ak Kranio-Facial (NIDCR)	Maladi Parodontal\|Dyabèt Melito, Kalite 2	17 oktòb 2001	Faz 2
NCT00064766	Eunice Kennedy Shriver Enstiti Nasyonal Sante Timoun ak Devlopman Imen (NICHD)	Senyen andometrial\|Maladi Peryodontal	Fevriye 2003	Faz 4
NCT00803452	Inivèsite Louisville	Blefarit	Jiyè 2008	Faz 4
NCT01434173	Bayer\|RTI Health Solutions	Blesi Fwa Dwòg Enduit	Jiyè 2001
NCT00126204	Lopital Barnes-Jwif	Aneurism aortik	Mas 2004	Pa aplikab
NCT01917721	Hawaii Pasifik Sante	Maladi Kawasaki\|Aneurism kowonè	Oktòb 2013	Faz 2
NCT02775695	Kolèj Medikal nan Wisconsin	Kansè pankreyas ki ka resekable	3 avril 2017	Faz 2
NCT03824340	Lopital Aljazeera	Sterilite	30 janvye 2019	Pa aplikab
NCT01847976	Ottawa Hospital Research Institute\|Canadian Breast Cancer Foundation	Doulè	Out 2013	Faz 2
NCT02850913	Makerere University\|University of Oxford	Kriz	5 septanm 2016	Faz 2
NCT00764361	NanoSHIFT LLC	Ilsè pye dyabetik	janvye 2009	Faz 2
NCT02036528	Royer Biomedical, Inc.	Ilsè pye dyabetik	Janvye 2014	Faz 1 \| Faz 2
NCT01661985	Konsèy Konte Ostergotland, Syèd\|Statens Serum Institut	Uretrit\|Sèvisit\|Enfeksyon Mikoplasm Jenital\|Klamidya Trachomatis	Fevriye 2010	Faz 4
NCT01380483	Par Pharmaceutical, Inc.\|Anapharm	Pou Detèmine Byoekivalans Anba Kondisyon Jèn	Janvye 2000	Faz 1
NCT00648180	Mylan Pharmaceuticals	An sante	Jiyè 2005	Faz 1
NCT01426269	Laboratwa Galderma, LP	Rosacée	Septanm 2011	Faz 4
NCT02753426	Inivèsite Kalifòni, San Francisco	Maladi ren kwonik\|Sendwòm kadyorenal	Avril 2016	Faz 1
NCT02583282	Enstiti postgraduate nan edikasyon medikal ak rechèch	Malfezan efizyon pleural	1ye Out 2015	Pa aplikab
NCT02927496	Gwoup Travay pou Sante Global\|Ajans Etazini pou Devlopman Entènasyonal (USAID)	Lenfedèm\|Filaryoz lenfatik\|Filaryoz	19 jen 2018	Faz 3
NCT00652795	Par Pharmaceutical, Inc.\|Anapharm	Pou Detèmine Byoekivalans Anba Kondisyon Jèn	Jiyè 2004	Faz 1
NCT03956212	University Medical Center Ljubljana\|University of Ljubljana School of Medicine, Sloveni	Eritem Migrans	1ye jen 2017	Pa aplikab
NCT00855595	Bayer	Papulopustular Rosacée	Fevriye 2009	Faz 4
NCT03457636	Derm Research, PLLC	Akne	19 mas 2018	Faz 4
NCT02894268	Sir Run Run Shaw Hospital	Enfeksyon Helicobacter Pylori	Fevriye 2016	Faz 4
NCT03465774	MD Anderson Cancer Center\|National Cancer Institute (NCI)	Malfezan efizyon pleural	8 mas 2018	Faz bonè 1